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Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—

Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin system (RAS). We evaluated aging phenotypes, especially skeletal muscle aging, in ACE2 systemically deficient (ACE2 KO) mice and found that ACE2 has a...

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Detalles Bibliográficos
Autores principales:	Takeshita, Hikari, Yamamoto, Koichi, Mogi, Masaki, Nozato, Satoko, Rakugi, Hiromi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925940/ https://www.ncbi.nlm.nih.gov/pubmed/36788301 http://dx.doi.org/10.1038/s41440-023-01189-y

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