Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer

Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromosomes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this re...

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Detalles Bibliográficos
Autores principales: Jin, Zheng, Peng, Fei, Zhang, Chao, Tao, Shuang, Xu, Damo, Zhu, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925975/
https://www.ncbi.nlm.nih.gov/pubmed/36798768
http://dx.doi.org/10.1016/j.heliyon.2023.e13195
Descripción
Sumario:Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromosomes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.

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