Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea

Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional an...

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Autores principales: Huang, Weijun, Zhang, Jingyu, Zou, Jianyin, Wang, Xiaoting, Xu, Huajun, Guan, Jian, Yi, Hongliang, Liu, Suru, Yin, Shankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926096/
https://www.ncbi.nlm.nih.gov/pubmed/36798439
http://dx.doi.org/10.1016/j.isci.2023.105985
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author Huang, Weijun
Zhang, Jingyu
Zou, Jianyin
Wang, Xiaoting
Xu, Huajun
Guan, Jian
Yi, Hongliang
Liu, Suru
Yin, Shankai
author_facet Huang, Weijun
Zhang, Jingyu
Zou, Jianyin
Wang, Xiaoting
Xu, Huajun
Guan, Jian
Yi, Hongliang
Liu, Suru
Yin, Shankai
author_sort Huang, Weijun
collection PubMed
description Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional and longitudinal analyses, the FGF21 level was associated with OSA. This analysis of two clinical cohorts is the first to show that the FGF21 level increased significantly with OSA severity and was an independent predictor of incident OSA in Chinese adults. The circulating FGF21 level could serve as a potential serum biomarker of OSA and its comorbidities and thus aid risk evaluation and early intervention.
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spelling pubmed-99260962023-02-15 Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea Huang, Weijun Zhang, Jingyu Zou, Jianyin Wang, Xiaoting Xu, Huajun Guan, Jian Yi, Hongliang Liu, Suru Yin, Shankai iScience Article Fibroblast growth factor 21 (FGF21) is a metabolic regulator and a potential biomarker of metabolic diseases. Limited data are available on the association between FGF21 and obstructive sleep apnea (OSA), which is considered as a manifestation of metabolic syndrome. In the present cross-sectional and longitudinal analyses, the FGF21 level was associated with OSA. This analysis of two clinical cohorts is the first to show that the FGF21 level increased significantly with OSA severity and was an independent predictor of incident OSA in Chinese adults. The circulating FGF21 level could serve as a potential serum biomarker of OSA and its comorbidities and thus aid risk evaluation and early intervention. Elsevier 2023-01-14 /pmc/articles/PMC9926096/ /pubmed/36798439 http://dx.doi.org/10.1016/j.isci.2023.105985 Text en © 2023. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Huang, Weijun
Zhang, Jingyu
Zou, Jianyin
Wang, Xiaoting
Xu, Huajun
Guan, Jian
Yi, Hongliang
Liu, Suru
Yin, Shankai
Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title_full Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title_fullStr Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title_full_unstemmed Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title_short Fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
title_sort fibroblast growth factor 21 is an independent predictor of prevalent and incident obstructive sleep apnea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926096/
https://www.ncbi.nlm.nih.gov/pubmed/36798439
http://dx.doi.org/10.1016/j.isci.2023.105985
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