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Relationship between methylenetetrahydrofolate reductase gene polymorphisms and methotrexate drug metabolism and toxicity

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, and methotrexate (MTX) is the key drug for ALL. Studies on the relationship between High-Dose methotrexate (HD-MTX) toxicity and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genes have drawn dif...

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Detalles Bibliográficos
Autores principales:	Tan, Yinli, Kong, Qian, Li, Xinyu, Tang, Yanlai, Mai, Huirong, Zhen, Zijun, Zhou, Dunhua, Chen, Huiqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926134/ https://www.ncbi.nlm.nih.gov/pubmed/36798930 http://dx.doi.org/10.21037/tp-22-671

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