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Left ventricular dysfunction in the immediate post-natal period
BACKGROUND: Our objective was to examine the clinical presentation, echocardiographic findings, and outcomes of newborns presenting with left ventricle (LV) dysfunction in the first 48 hours of life without perinatal asphyxia or structural heart disease. We hypothesize that LV dysfunction may occur...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926136/ https://www.ncbi.nlm.nih.gov/pubmed/36798933 http://dx.doi.org/10.21037/tp-22-301 |
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author | Vijayashankar, Sakethram S. Sanatani, Gabrielle Franciosi, Sonia Moodley, Shreya Ting, Joseph Y. |
author_facet | Vijayashankar, Sakethram S. Sanatani, Gabrielle Franciosi, Sonia Moodley, Shreya Ting, Joseph Y. |
author_sort | Vijayashankar, Sakethram S. |
collection | PubMed |
description | BACKGROUND: Our objective was to examine the clinical presentation, echocardiographic findings, and outcomes of newborns presenting with left ventricle (LV) dysfunction in the first 48 hours of life without perinatal asphyxia or structural heart disease. We hypothesize that LV dysfunction may occur due to maladaptation to extrauterine life. METHODS: This is a retrospective cohort analysis including infants born in a quaternary perinatal centre. Late preterm and term neonates who were diagnosed with left ventricular dysfunction at less than 48 hours of life were identified using an echocardiography clinical laboratory’s database and extracorporeal life support database. LV dysfunction was defined as m-mode fractional shortening (FS) <28% or ejection fraction (EF) <50% on echocardiography or reduced function reported by a cardiologist. Data extracted included patient & maternal demographics, echocardiogram parameters, clinical status, and medications. The primary outcome measure was time to recovery of LV function based on echocardiography. RESULTS: Of the 69 patients identified, 19 patients were included in the final analysis. The mean gestational age was 38 weeks. Thirteen (68%) infants did not have an underlying cause identified despite extensive work-up. Four (21%) infants had exposure to maternal illicit drug use during pregnancy. Three infants died, and all infants without identifiable etiologies had recovery of LV function within 14 days of life. CONCLUSIONS: LV dysfunction can occur during the abrupt transition from fetal to neonatal circulation and can be associated with maternal illicit drug use. |
format | Online Article Text |
id | pubmed-9926136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-99261362023-02-15 Left ventricular dysfunction in the immediate post-natal period Vijayashankar, Sakethram S. Sanatani, Gabrielle Franciosi, Sonia Moodley, Shreya Ting, Joseph Y. Transl Pediatr Original Article BACKGROUND: Our objective was to examine the clinical presentation, echocardiographic findings, and outcomes of newborns presenting with left ventricle (LV) dysfunction in the first 48 hours of life without perinatal asphyxia or structural heart disease. We hypothesize that LV dysfunction may occur due to maladaptation to extrauterine life. METHODS: This is a retrospective cohort analysis including infants born in a quaternary perinatal centre. Late preterm and term neonates who were diagnosed with left ventricular dysfunction at less than 48 hours of life were identified using an echocardiography clinical laboratory’s database and extracorporeal life support database. LV dysfunction was defined as m-mode fractional shortening (FS) <28% or ejection fraction (EF) <50% on echocardiography or reduced function reported by a cardiologist. Data extracted included patient & maternal demographics, echocardiogram parameters, clinical status, and medications. The primary outcome measure was time to recovery of LV function based on echocardiography. RESULTS: Of the 69 patients identified, 19 patients were included in the final analysis. The mean gestational age was 38 weeks. Thirteen (68%) infants did not have an underlying cause identified despite extensive work-up. Four (21%) infants had exposure to maternal illicit drug use during pregnancy. Three infants died, and all infants without identifiable etiologies had recovery of LV function within 14 days of life. CONCLUSIONS: LV dysfunction can occur during the abrupt transition from fetal to neonatal circulation and can be associated with maternal illicit drug use. AME Publishing Company 2022-12-13 2023-01-31 /pmc/articles/PMC9926136/ /pubmed/36798933 http://dx.doi.org/10.21037/tp-22-301 Text en 2023 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Vijayashankar, Sakethram S. Sanatani, Gabrielle Franciosi, Sonia Moodley, Shreya Ting, Joseph Y. Left ventricular dysfunction in the immediate post-natal period |
title | Left ventricular dysfunction in the immediate post-natal period |
title_full | Left ventricular dysfunction in the immediate post-natal period |
title_fullStr | Left ventricular dysfunction in the immediate post-natal period |
title_full_unstemmed | Left ventricular dysfunction in the immediate post-natal period |
title_short | Left ventricular dysfunction in the immediate post-natal period |
title_sort | left ventricular dysfunction in the immediate post-natal period |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926136/ https://www.ncbi.nlm.nih.gov/pubmed/36798933 http://dx.doi.org/10.21037/tp-22-301 |
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