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Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review

The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical,...

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Autores principales: Săndulescu, Maria Sidonia, Văduva, Constantin-Cristian, Siminel, Mirela Anişoara, Dijmărescu, Anda Lorena, Vrabie, Sidonia Cătălina, Camen, Ioana Victoria, Tache, Daniela Elise, Neamţu, Simona Daniela, Nagy, Rodica Daniela, Carp-Velişcu, Andreea, Manolea, Maria Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926143/
https://www.ncbi.nlm.nih.gov/pubmed/36588488
http://dx.doi.org/10.47162/RJME.63.3.04
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author Săndulescu, Maria Sidonia
Văduva, Constantin-Cristian
Siminel, Mirela Anişoara
Dijmărescu, Anda Lorena
Vrabie, Sidonia Cătălina
Camen, Ioana Victoria
Tache, Daniela Elise
Neamţu, Simona Daniela
Nagy, Rodica Daniela
Carp-Velişcu, Andreea
Manolea, Maria Magdalena
author_facet Săndulescu, Maria Sidonia
Văduva, Constantin-Cristian
Siminel, Mirela Anişoara
Dijmărescu, Anda Lorena
Vrabie, Sidonia Cătălina
Camen, Ioana Victoria
Tache, Daniela Elise
Neamţu, Simona Daniela
Nagy, Rodica Daniela
Carp-Velişcu, Andreea
Manolea, Maria Magdalena
author_sort Săndulescu, Maria Sidonia
collection PubMed
description The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical, social, economic, and political instability. The aim of this study was to make an analysis of the scientific data obtained by so far to highlight the impact that COVID-19 has had on fertility and assisted reproductive technology (ART). Infection with SARS-CoV-2 alters the normal immune response by local and systemic damage to tissues and organs. After the virus enters the body, the first lesions are produced in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage, hepatocellular lesions, neurological diseases, myocardial dysfunction and arrhythmia, gastrointestinal diseases but also genital impairment. The possible impairment of the male reproductive system is because angiotensin-converting enzyme 2 (ACE2) receptors are in an increased number in the testes, seminiferous duct cells, spermatogonia, Leydig cells and Sertoli cells. Many published studies to date have pointed out that COVID-19 could also affect female fertility and disrupt the functions of the female reproductive system. The theory that this virus can also be transmitted sexually and can cause infertility or testicular damage is supported by the fact that the virus can be isolated in the semen of COVID-19 patients but only during the disease. Choosing the best method of treating infertility during the COVID-19 pandemic is multifactorial, but the risk of infection and compliance with specific ART hygiene protocols must always be considered. Currently, there is no scientific basis regarding the fact that the COVID-19 vaccination would influence fertility.
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spelling pubmed-99261432023-02-15 Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review Săndulescu, Maria Sidonia Văduva, Constantin-Cristian Siminel, Mirela Anişoara Dijmărescu, Anda Lorena Vrabie, Sidonia Cătălina Camen, Ioana Victoria Tache, Daniela Elise Neamţu, Simona Daniela Nagy, Rodica Daniela Carp-Velişcu, Andreea Manolea, Maria Magdalena Rom J Morphol Embryol Review The appearance of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major obstacle for the performing of current medical activities throughout the world. COVID-19 has affected humanity in many ways, thus causing a great medical, social, economic, and political instability. The aim of this study was to make an analysis of the scientific data obtained by so far to highlight the impact that COVID-19 has had on fertility and assisted reproductive technology (ART). Infection with SARS-CoV-2 alters the normal immune response by local and systemic damage to tissues and organs. After the virus enters the body, the first lesions are produced in the respiratory tract. Extrapulmonary lesions specific to COVID-19 include acute renal lesions/acute kidney damage, hepatocellular lesions, neurological diseases, myocardial dysfunction and arrhythmia, gastrointestinal diseases but also genital impairment. The possible impairment of the male reproductive system is because angiotensin-converting enzyme 2 (ACE2) receptors are in an increased number in the testes, seminiferous duct cells, spermatogonia, Leydig cells and Sertoli cells. Many published studies to date have pointed out that COVID-19 could also affect female fertility and disrupt the functions of the female reproductive system. The theory that this virus can also be transmitted sexually and can cause infertility or testicular damage is supported by the fact that the virus can be isolated in the semen of COVID-19 patients but only during the disease. Choosing the best method of treating infertility during the COVID-19 pandemic is multifactorial, but the risk of infection and compliance with specific ART hygiene protocols must always be considered. Currently, there is no scientific basis regarding the fact that the COVID-19 vaccination would influence fertility. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2022 2022-09-30 /pmc/articles/PMC9926143/ /pubmed/36588488 http://dx.doi.org/10.47162/RJME.63.3.04 Text en Copyright © 2022, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Review
Săndulescu, Maria Sidonia
Văduva, Constantin-Cristian
Siminel, Mirela Anişoara
Dijmărescu, Anda Lorena
Vrabie, Sidonia Cătălina
Camen, Ioana Victoria
Tache, Daniela Elise
Neamţu, Simona Daniela
Nagy, Rodica Daniela
Carp-Velişcu, Andreea
Manolea, Maria Magdalena
Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title_full Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title_fullStr Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title_full_unstemmed Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title_short Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review
title_sort impact of covid-19 on fertility and assisted reproductive technology (art): a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926143/
https://www.ncbi.nlm.nih.gov/pubmed/36588488
http://dx.doi.org/10.47162/RJME.63.3.04
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