Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin

Iron homeostasis is critical for cellular and organismal function and is tightly regulated to prevent toxicity or anemia due to iron excess or deficiency, respectively. However, subcellular regulatory mechanisms of iron remain largely unexplored. Here, we report that SEL1L-HRD1 protein complex of en...

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Detalles Bibliográficos
Autores principales: Thepsuwan, Pattaraporn, Bhattacharya, Asmita, Song, Zhenfeng, Hippleheuser, Stephen, Feng, Shaobin, Wei, Xiaoqiong, Das, Nupur K., Sierra, Mariana, Wei, Juncheng, Fang, Deyu, Huang, Yu-ming M., Zhang, Kezhong, Shah, Yatrik M., Sun, Shengyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926173/
https://www.ncbi.nlm.nih.gov/pubmed/36595688
http://dx.doi.org/10.1073/pnas.2212644120

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