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pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain

We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial Alzheimer's disease mutation (5XFAD) mice. In...

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Detalles Bibliográficos
Autores principales:	Kim, Sehwan, Sharma, Chanchal, Shin, Minsang, Kim, Hyung-Jun, Kim, Jaekwang, Kim, Sang Ryong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926212/ https://www.ncbi.nlm.nih.gov/pubmed/36798617 http://dx.doi.org/10.1016/j.bbih.2023.100593

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