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Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis
Many epithelial compartments undergo constitutive renewal in homeostasis but activate unique regenerative responses following injury. The clear corneal epithelium is crucial for vision and is renewed from limbal stem cells (LSCs). Using single-cell RNA sequencing, we profiled the mouse corneal epith...
Autores principales: | Lin, Joseph B., Shen, Xiaolei, Pfeifer, Charles W., Shiau, Fion, Santeford, Andrea, Ruzycki, Philip A., Clark, Brian S., Liu, Qin, Huang, Andrew J. W., Apte, Rajendra S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926235/ https://www.ncbi.nlm.nih.gov/pubmed/36595669 http://dx.doi.org/10.1073/pnas.2204134120 |
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