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Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism
CD4(+) memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling the redox metabolism in memory T cell formation re...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926250/ https://www.ncbi.nlm.nih.gov/pubmed/36595680 http://dx.doi.org/10.1073/pnas.2218345120 |
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author | Kokubo, Kota Hirahara, Kiyoshi Kiuchi, Masahiro Tsuji, Kaori Shimada, Yuki Sonobe, Yuri Shinmi, Rie Hishiya, Takahisa Iwamura, Chiaki Onodera, Atsushi Nakayama, Toshinori |
author_facet | Kokubo, Kota Hirahara, Kiyoshi Kiuchi, Masahiro Tsuji, Kaori Shimada, Yuki Sonobe, Yuri Shinmi, Rie Hishiya, Takahisa Iwamura, Chiaki Onodera, Atsushi Nakayama, Toshinori |
author_sort | Kokubo, Kota |
collection | PubMed |
description | CD4(+) memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling the redox metabolism in memory T cell formation remain unclear. We found that reactive oxygen species (ROS) metabolism changed dramatically in T helper-2 (Th2) cells during the contraction phase in the process of memory T cell formation. Thioredoxin-interacting protein (Txnip), a regulator of oxidoreductase, regulated apoptosis by scavenging ROS via the nuclear factor erythroid 2-related factor 2 (Nrf2)–biliverdin reductase B (Blvrb) pathway. Txnip regulated the pathology of chronic airway inflammation in the lung by controlling the generation of allergen-specific pathogenic memory Th2 cells in vivo. Thus, the Txnip–Nrf2–Blvrb axis directs ROS metabolic reprogramming in Th2 cells and is a potential therapeutic target for intractable chronic inflammatory diseases. |
format | Online Article Text |
id | pubmed-9926250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-99262502023-07-03 Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism Kokubo, Kota Hirahara, Kiyoshi Kiuchi, Masahiro Tsuji, Kaori Shimada, Yuki Sonobe, Yuri Shinmi, Rie Hishiya, Takahisa Iwamura, Chiaki Onodera, Atsushi Nakayama, Toshinori Proc Natl Acad Sci U S A Biological Sciences CD4(+) memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling the redox metabolism in memory T cell formation remain unclear. We found that reactive oxygen species (ROS) metabolism changed dramatically in T helper-2 (Th2) cells during the contraction phase in the process of memory T cell formation. Thioredoxin-interacting protein (Txnip), a regulator of oxidoreductase, regulated apoptosis by scavenging ROS via the nuclear factor erythroid 2-related factor 2 (Nrf2)–biliverdin reductase B (Blvrb) pathway. Txnip regulated the pathology of chronic airway inflammation in the lung by controlling the generation of allergen-specific pathogenic memory Th2 cells in vivo. Thus, the Txnip–Nrf2–Blvrb axis directs ROS metabolic reprogramming in Th2 cells and is a potential therapeutic target for intractable chronic inflammatory diseases. National Academy of Sciences 2023-01-03 2023-01-10 /pmc/articles/PMC9926250/ /pubmed/36595680 http://dx.doi.org/10.1073/pnas.2218345120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Kokubo, Kota Hirahara, Kiyoshi Kiuchi, Masahiro Tsuji, Kaori Shimada, Yuki Sonobe, Yuri Shinmi, Rie Hishiya, Takahisa Iwamura, Chiaki Onodera, Atsushi Nakayama, Toshinori Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title | Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title_full | Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title_fullStr | Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title_full_unstemmed | Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title_short | Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism |
title_sort | thioredoxin-interacting protein is essential for memory t cell formation via the regulation of the redox metabolism |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926250/ https://www.ncbi.nlm.nih.gov/pubmed/36595680 http://dx.doi.org/10.1073/pnas.2218345120 |
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