Feedback in the β-catenin destruction complex imparts bistability and cellular memory

Wnt ligands are considered classical morphogens, for which the strength of the cellular response is proportional to the concentration of the ligand. Herein, we show an emergent property of bistability arising from feedback among the Wnt destruction complex proteins that target the key transcriptiona...

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Detalles Bibliográficos
Autores principales: Cantoria, Mary Jo, Alizadeh, Elaheh, Ravi, Janani, Varghese, Reeba P., Bunnag, Nawat, Pond, Kelvin W., Kettenbach, Arminja N., Ahmed, Yashi, Paek, Andrew L., Tyson, John J., Doubrovinski, Konstantin, Lee, Ethan, Thorne, Curtis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926258/
https://www.ncbi.nlm.nih.gov/pubmed/36598937
http://dx.doi.org/10.1073/pnas.2208787120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926258/
https://www.ncbi.nlm.nih.gov/pubmed/36598937
http://dx.doi.org/10.1073/pnas.2208787120

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