Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors

Chimeric antigen receptors (CARs) can redirect T cells to target abnormal cells, but their activity is limited by a profound defect in antigen sensitivity, the source of which remains unclear. Here, we show that CARs have a > 100-fold lower antigen sensitivity compared to the T cell receptor (TCR...

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Detalles Bibliográficos
Autores principales: Burton, Jake, Siller-Farfán, Jesús A., Pettmann, Johannes, Salzer, Benjamin, Kutuzov, Mikhail, van der Merwe, P. Anton, Dushek, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926289/
https://www.ncbi.nlm.nih.gov/pubmed/36598945
http://dx.doi.org/10.1073/pnas.2216352120

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