Disruption of the interaction between mutationally activated Gα(q) and Gβγ attenuates aberrant signaling

Heterotrimeric G protein stimulation via G protein–coupled receptors promotes downstream proliferative signaling. Mutations can occur in Gα proteins which prevent GTP hydrolysis; this allows the G proteins to signal independently of G protein–coupled receptors and can result in various cancers, such...

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Detalles Bibliográficos
Autores principales: Aumiller, Jenna L., Wedegaertner, Philip B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926304/
https://www.ncbi.nlm.nih.gov/pubmed/36626984
http://dx.doi.org/10.1016/j.jbc.2023.102880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926304/
https://www.ncbi.nlm.nih.gov/pubmed/36626984
http://dx.doi.org/10.1016/j.jbc.2023.102880

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