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Disruption of the interaction between mutationally activated Gα(q) and Gβγ attenuates aberrant signaling
Heterotrimeric G protein stimulation via G protein–coupled receptors promotes downstream proliferative signaling. Mutations can occur in Gα proteins which prevent GTP hydrolysis; this allows the G proteins to signal independently of G protein–coupled receptors and can result in various cancers, such...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926304/ https://www.ncbi.nlm.nih.gov/pubmed/36626984 http://dx.doi.org/10.1016/j.jbc.2023.102880 |