Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus

Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallopht...

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Autores principales: Koifman, O. I., Maizlish, V. E., Koifman, M. O., Lebedeva, N. Sh., Yurina, E. S., Gubarev, Yu. A., Gur’ev, E. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Full Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926408/
https://www.ncbi.nlm.nih.gov/pubmed/36817559
http://dx.doi.org/10.1007/s11172-023-3728-y
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author Koifman, O. I.
Maizlish, V. E.
Koifman, M. O.
Lebedeva, N. Sh.
Yurina, E. S.
Gubarev, Yu. A.
Gur’ev, E. L.
author_facet Koifman, O. I.
Maizlish, V. E.
Koifman, M. O.
Lebedeva, N. Sh.
Yurina, E. S.
Gubarev, Yu. A.
Gur’ev, E. L.
author_sort Koifman, O. I.
collection PubMed
description Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain. The photoirradiation of the complex of ORF3a protein of SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine leads to the photooxidation of amino acid residues of the protein.
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spelling pubmed-99264082023-02-14 Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus Koifman, O. I. Maizlish, V. E. Koifman, M. O. Lebedeva, N. Sh. Yurina, E. S. Gubarev, Yu. A. Gur’ev, E. L. Russ Chem Bull Full Articles Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain. The photoirradiation of the complex of ORF3a protein of SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine leads to the photooxidation of amino acid residues of the protein. Springer US 2023-02-14 2023 /pmc/articles/PMC9926408/ /pubmed/36817559 http://dx.doi.org/10.1007/s11172-023-3728-y Text en © Springer Science+Business Media LLC 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Full Articles
Koifman, O. I.
Maizlish, V. E.
Koifman, M. O.
Lebedeva, N. Sh.
Yurina, E. S.
Gubarev, Yu. A.
Gur’ev, E. L.
Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title_full Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title_fullStr Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title_full_unstemmed Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title_short Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus
title_sort complexation ability of tetrasulfosubstituted cobalt(ii) phthalocyanine toward orf3a protein of sars-cov-2 virus
topic Full Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926408/
https://www.ncbi.nlm.nih.gov/pubmed/36817559
http://dx.doi.org/10.1007/s11172-023-3728-y
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