Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication

A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cyt...

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Autores principales: Paramonova, M. P., Gureeva, E. S., Ozerov, A. A., Snoeck, R., Andrei, G., Alexandrov, D. A., Handazinskaya, A. L., Novikov, M. S., Kochetkov, S. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926436/
https://www.ncbi.nlm.nih.gov/pubmed/36787002
http://dx.doi.org/10.1134/S1607672922340099
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author Paramonova, M. P.
Gureeva, E. S.
Ozerov, A. A.
Snoeck, R.
Andrei, G.
Alexandrov, D. A.
Handazinskaya, A. L.
Novikov, M. S.
Kochetkov, S. N.
author_facet Paramonova, M. P.
Gureeva, E. S.
Ozerov, A. A.
Snoeck, R.
Andrei, G.
Alexandrov, D. A.
Handazinskaya, A. L.
Novikov, M. S.
Kochetkov, S. N.
author_sort Paramonova, M. P.
collection PubMed
description A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cytomegalovirus were studied. It was found that the compound containing a bridge consisting of five methylene groups exhibits a high anti-cytomegalovirus activity in vitro.
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spelling pubmed-99264362023-02-14 Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication Paramonova, M. P. Gureeva, E. S. Ozerov, A. A. Snoeck, R. Andrei, G. Alexandrov, D. A. Handazinskaya, A. L. Novikov, M. S. Kochetkov, S. N. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cytomegalovirus were studied. It was found that the compound containing a bridge consisting of five methylene groups exhibits a high anti-cytomegalovirus activity in vitro. Pleiades Publishing 2023-02-14 2022 /pmc/articles/PMC9926436/ /pubmed/36787002 http://dx.doi.org/10.1134/S1607672922340099 Text en © Pleiades Publishing, Ltd. 2022, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 507, pp. 357–362. © Pleiades Publishing, Ltd., 2022. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Paramonova, M. P.
Gureeva, E. S.
Ozerov, A. A.
Snoeck, R.
Andrei, G.
Alexandrov, D. A.
Handazinskaya, A. L.
Novikov, M. S.
Kochetkov, S. N.
Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title_full Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title_fullStr Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title_full_unstemmed Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title_short Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication
title_sort synthesis of 1-[ω-(bromophenoxy)alkyl]-3-naphthalenylmethyl uracil derivatives and their analogues as probable inhibitors of human cytomegalovirus replication
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926436/
https://www.ncbi.nlm.nih.gov/pubmed/36787002
http://dx.doi.org/10.1134/S1607672922340099
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