Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of...

Descripción completa

Detalles Bibliográficos
Autores principales: Shchegravina, E. S., Usova, S. D., Baev, D. S., Mozhaitsev, E. S., Shcherbakov, D. N., Belenkaya, S. V., Volosnikova, E. A., Chirkova, V. Yu., Sharlaeva, E. A., Svirshchevskaya, E. V., Fonareva, I. P., Sitdikova, A. R., Salakhutdinov, N. F., Yarovaya, O. I., Fedorov, A. Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Full Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926439/
https://www.ncbi.nlm.nih.gov/pubmed/36817557
http://dx.doi.org/10.1007/s11172-023-3730-4
Descripción
Sumario:Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

Ejemplares similares