Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of...

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Autores principales: Shchegravina, E. S., Usova, S. D., Baev, D. S., Mozhaitsev, E. S., Shcherbakov, D. N., Belenkaya, S. V., Volosnikova, E. A., Chirkova, V. Yu., Sharlaeva, E. A., Svirshchevskaya, E. V., Fonareva, I. P., Sitdikova, A. R., Salakhutdinov, N. F., Yarovaya, O. I., Fedorov, A. Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Full Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926439/
https://www.ncbi.nlm.nih.gov/pubmed/36817557
http://dx.doi.org/10.1007/s11172-023-3730-4
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author Shchegravina, E. S.
Usova, S. D.
Baev, D. S.
Mozhaitsev, E. S.
Shcherbakov, D. N.
Belenkaya, S. V.
Volosnikova, E. A.
Chirkova, V. Yu.
Sharlaeva, E. A.
Svirshchevskaya, E. V.
Fonareva, I. P.
Sitdikova, A. R.
Salakhutdinov, N. F.
Yarovaya, O. I.
Fedorov, A. Yu.
author_facet Shchegravina, E. S.
Usova, S. D.
Baev, D. S.
Mozhaitsev, E. S.
Shcherbakov, D. N.
Belenkaya, S. V.
Volosnikova, E. A.
Chirkova, V. Yu.
Sharlaeva, E. A.
Svirshchevskaya, E. V.
Fonareva, I. P.
Sitdikova, A. R.
Salakhutdinov, N. F.
Yarovaya, O. I.
Fedorov, A. Yu.
author_sort Shchegravina, E. S.
collection PubMed
description Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.
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spelling pubmed-99264392023-02-14 Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity Shchegravina, E. S. Usova, S. D. Baev, D. S. Mozhaitsev, E. S. Shcherbakov, D. N. Belenkaya, S. V. Volosnikova, E. A. Chirkova, V. Yu. Sharlaeva, E. A. Svirshchevskaya, E. V. Fonareva, I. P. Sitdikova, A. R. Salakhutdinov, N. F. Yarovaya, O. I. Fedorov, A. Yu. Russ Chem Bull Full Articles Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied. Springer US 2023-02-14 2023 /pmc/articles/PMC9926439/ /pubmed/36817557 http://dx.doi.org/10.1007/s11172-023-3730-4 Text en © Springer Science+Business Media LLC 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Full Articles
Shchegravina, E. S.
Usova, S. D.
Baev, D. S.
Mozhaitsev, E. S.
Shcherbakov, D. N.
Belenkaya, S. V.
Volosnikova, E. A.
Chirkova, V. Yu.
Sharlaeva, E. A.
Svirshchevskaya, E. V.
Fonareva, I. P.
Sitdikova, A. R.
Salakhutdinov, N. F.
Yarovaya, O. I.
Fedorov, A. Yu.
Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title_full Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title_fullStr Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title_full_unstemmed Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title_short Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
title_sort synthesis of conjugates of (ar,7s)-colchicine with monoterpenoids and investigation of their biological activity
topic Full Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926439/
https://www.ncbi.nlm.nih.gov/pubmed/36817557
http://dx.doi.org/10.1007/s11172-023-3730-4
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