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Partial mimicry of the microtubule binding of tau by its membrane binding

Tau, as typical of intrinsically disordered proteins (IDPs), binds to multiple targets including microtubules and acidic membranes. The latter two surfaces are both highly negatively charged, raising the prospect of mimicry in their binding by tau. The tau‐microtubule complex was recently determined...

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Detalles Bibliográficos
Autores principales: MacAinsh, Matthew, Zhou, Huan‐Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926470/
https://www.ncbi.nlm.nih.gov/pubmed/36710643
http://dx.doi.org/10.1002/pro.4581