Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis

[Image: see text] Mycobacterium tuberculosis cytochrome bd quinol oxidase (cyt bd), the alternative terminal oxidase of the respiratory chain, has been identified as playing a key role during chronic infection and presents a putative target for the development of novel antitubercular agents. Here, w...

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Detalles Bibliográficos
Autores principales: Jeffreys, Laura N., Ardrey, Alison, Hafiz, Taghreed A., Dyer, Lauri-Anne, Warman, Ashley J., Mosallam, Nada, Nixon, Gemma L., Fisher, Nicholas E., Hong, W. David, Leung, Suet C., Aljayyoussi, Ghaith, Bibby, Jaclyn, Almeida, Deepak V., Converse, Paul J., Fotouhi, Nader, Berry, Neil G., Nuermberger, Eric L., Upton, Anna M., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926492/
https://www.ncbi.nlm.nih.gov/pubmed/36606559
http://dx.doi.org/10.1021/acsinfecdis.2c00283

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