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Emerging roles of tRNA-derived fragments in cancer

tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physio...

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Autores principales: Fu, Min, Gu, Jianmei, Wang, Maoye, Zhang, Jiahui, Chen, Yanke, Jiang, Pengcheng, Zhu, Taofeng, Zhang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926655/
https://www.ncbi.nlm.nih.gov/pubmed/36782290
http://dx.doi.org/10.1186/s12943-023-01739-5
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author Fu, Min
Gu, Jianmei
Wang, Maoye
Zhang, Jiahui
Chen, Yanke
Jiang, Pengcheng
Zhu, Taofeng
Zhang, Xu
author_facet Fu, Min
Gu, Jianmei
Wang, Maoye
Zhang, Jiahui
Chen, Yanke
Jiang, Pengcheng
Zhu, Taofeng
Zhang, Xu
author_sort Fu, Min
collection PubMed
description tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physiological and pathophysiological processes. tRFs can regulate cell viability, differentiation, and homeostasis through multiple mechanisms and are thus considered as critical regulators of human diseases including cancer. In addition, increasing evidence suggest the extracellular tRFs may be utilized as promising diagnostic and prognostic biomarkers for cancer liquid biopsy. In this review, we focus on the biogenesis, classification and modification of tRFs, and summarize the multifaceted functions of tRFs with an emphasis on the current research status and perspectives of tRFs in cancer.
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spelling pubmed-99266552023-02-15 Emerging roles of tRNA-derived fragments in cancer Fu, Min Gu, Jianmei Wang, Maoye Zhang, Jiahui Chen, Yanke Jiang, Pengcheng Zhu, Taofeng Zhang, Xu Mol Cancer Review tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of tRFs with critical functions in distinct physiological and pathophysiological processes. tRFs can regulate cell viability, differentiation, and homeostasis through multiple mechanisms and are thus considered as critical regulators of human diseases including cancer. In addition, increasing evidence suggest the extracellular tRFs may be utilized as promising diagnostic and prognostic biomarkers for cancer liquid biopsy. In this review, we focus on the biogenesis, classification and modification of tRFs, and summarize the multifaceted functions of tRFs with an emphasis on the current research status and perspectives of tRFs in cancer. BioMed Central 2023-02-13 /pmc/articles/PMC9926655/ /pubmed/36782290 http://dx.doi.org/10.1186/s12943-023-01739-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fu, Min
Gu, Jianmei
Wang, Maoye
Zhang, Jiahui
Chen, Yanke
Jiang, Pengcheng
Zhu, Taofeng
Zhang, Xu
Emerging roles of tRNA-derived fragments in cancer
title Emerging roles of tRNA-derived fragments in cancer
title_full Emerging roles of tRNA-derived fragments in cancer
title_fullStr Emerging roles of tRNA-derived fragments in cancer
title_full_unstemmed Emerging roles of tRNA-derived fragments in cancer
title_short Emerging roles of tRNA-derived fragments in cancer
title_sort emerging roles of trna-derived fragments in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926655/
https://www.ncbi.nlm.nih.gov/pubmed/36782290
http://dx.doi.org/10.1186/s12943-023-01739-5
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