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H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells

BACKGROUND: The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible, creating an environment that is permissive to transcription factor binding and the recruitment of transcriptional coactivators tha...

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Detalles Bibliográficos
Autores principales: Tafessu, Amanuel, O’Hara, Ryan, Martire, Sara, Dube, Altair L., Saha, Purbita, Gant, Vincent U., Banaszynski, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926682/
https://www.ncbi.nlm.nih.gov/pubmed/36782260
http://dx.doi.org/10.1186/s13059-023-02867-3