α-Synuclein induces prodromal symptoms of Parkinson’s disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model

BACKGROUND: Increasing evidence suggests that patients with Parkinson's disease (PD) present with peripheral autonomic dysfunction (AutD) that even precedes motor deficits, through which α-synuclein can spread to the central nervous system. However, the pathological mechanisms underlying AutD i...

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Detalles Bibliográficos
Autores principales: Cheng, Yue, Tong, Qing, Yuan, Yongsheng, Song, Xinna, Jiang, Wenwen, Wang, Yueping, Li, Wenjie, Li, Yangxia, Zhang, Kezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926693/
https://www.ncbi.nlm.nih.gov/pubmed/36788559
http://dx.doi.org/10.1186/s12974-023-02720-1

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