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Circadian disruption and sleep disorders in neurodegeneration

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption an...

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Autores principales: Shen, Yun, Lv, Qian-kun, Xie, Wei-ye, Gong, Si-yi, Zhuang, Sheng, Liu, Jun-yi, Mao, Cheng-jie, Liu, Chun-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926748/
https://www.ncbi.nlm.nih.gov/pubmed/36782262
http://dx.doi.org/10.1186/s40035-023-00340-6
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author Shen, Yun
Lv, Qian-kun
Xie, Wei-ye
Gong, Si-yi
Zhuang, Sheng
Liu, Jun-yi
Mao, Cheng-jie
Liu, Chun-feng
author_facet Shen, Yun
Lv, Qian-kun
Xie, Wei-ye
Gong, Si-yi
Zhuang, Sheng
Liu, Jun-yi
Mao, Cheng-jie
Liu, Chun-feng
author_sort Shen, Yun
collection PubMed
description Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.
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spelling pubmed-99267482023-02-15 Circadian disruption and sleep disorders in neurodegeneration Shen, Yun Lv, Qian-kun Xie, Wei-ye Gong, Si-yi Zhuang, Sheng Liu, Jun-yi Mao, Cheng-jie Liu, Chun-feng Transl Neurodegener Review Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions. BioMed Central 2023-02-13 /pmc/articles/PMC9926748/ /pubmed/36782262 http://dx.doi.org/10.1186/s40035-023-00340-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Shen, Yun
Lv, Qian-kun
Xie, Wei-ye
Gong, Si-yi
Zhuang, Sheng
Liu, Jun-yi
Mao, Cheng-jie
Liu, Chun-feng
Circadian disruption and sleep disorders in neurodegeneration
title Circadian disruption and sleep disorders in neurodegeneration
title_full Circadian disruption and sleep disorders in neurodegeneration
title_fullStr Circadian disruption and sleep disorders in neurodegeneration
title_full_unstemmed Circadian disruption and sleep disorders in neurodegeneration
title_short Circadian disruption and sleep disorders in neurodegeneration
title_sort circadian disruption and sleep disorders in neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926748/
https://www.ncbi.nlm.nih.gov/pubmed/36782262
http://dx.doi.org/10.1186/s40035-023-00340-6
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