Correlation Between Mean Amplitude of Glycemic Excursion and Bone Turnover Markers in Patients with Type 2 Diabetes: A Cross-Sectional Study

OBJECTIVE: The present study explores the relationship between glycemic excursion and bone turnover markers. METHODS: A total of 250 patients with type 2 diabetes mellitus (T2DM) (142 female and 108 male patients) were enrolled in this study. All participants underwent 72 hours of continuous glycemic monitoring to evaluate the mean amplitude of glycemic excursions (MAGE) of each person. Bone turnover markers and other biochemical data were measured for each patient. Linear regression was performed to explore the relationship between bone turnover markers and glycemic excursion. A value of P < 0.05 was considered statistically significant. RESULTS: MAGE was negatively correlated to N-terminal propeptide of type 1 collagen (P1NP) female: [odds ratios (95% confidence interval) (OR (95% CI)), −2.516 (−5.389, 0.356)]; male: [−2.895, (−6.521, −0.731)] and C-terminal telopeptide fragments of type-I collagen (β-CTX) female [−0.025, (−0.036, 0.005)]; male [−0.043, (−0.082, 0.003)]. MAGE was still negatively correlated with β-CTX female [−0.036, (−0.198, −0.030)]; male [−0.048, (−0.089, −0.007)] after adjusting for clinical data and biochemical indices. CONCLUSION: An independent negative relationship between glycemic excursion and bone turnover markers in patients with T2DM was identified in this study.