Safety and efficacy of first-in-man intrathecal injection of human astrocytes (AstroRx®) in ALS patients: phase I/IIa clinical trial results

BACKGROUND: Malfunction of astrocytes is implicated as one of the pathological factors of ALS. Thus, intrathecal injection of healthy astrocytes in ALS can potentially compensate for the diseased astrocytes. AstroRx® is an allogeneic cell-based product, composed of healthy and functional human astro...

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Detalles Bibliográficos
Autores principales: Gotkine, Marc, Caraco, Yoseph, Lerner, Yossef, Blotnick, Simcha, Wanounou, Maor, Slutsky, Shalom Guy, Chebath, Judith, Kuperstein, Graciela, Estrin, Elena, Ben-Hur, Tamir, Hasson, Arik, Molakandov, Kfir, Sonnenfeld, Tehila, Stark, Yafit, Revel, Ariel, Revel, Michel, Izrael, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927047/
https://www.ncbi.nlm.nih.gov/pubmed/36788520
http://dx.doi.org/10.1186/s12967-023-03903-3

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