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Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux

BACKGROUND: Inhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts most of its function by binding to S1P receptors (S1PR1-5). The roles of S1P receptors in NLRP3 inflammasome activation remain u...

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Detalles Bibliográficos
Autores principales:	Wang, Yingqin, Wang, Chen, He, Qiaolan, Chen, Guannan, Yu, Jie, Cang, Jing, Zhong, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927198/ https://www.ncbi.nlm.nih.gov/pubmed/36798132 http://dx.doi.org/10.3389/fimmu.2023.1090202

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