Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone

Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevat...

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Autores principales: Liu, Huazhen, Gao, Dan, Huang, Yongfa, Li, Ji, Zhao, Mengyun, Lu, Zhaohui, Hu, Ya, Wang, Tao, Zhang, Yingqiang, Wang, Wenze, Cao, Dongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927209/
https://www.ncbi.nlm.nih.gov/pubmed/36798668
http://dx.doi.org/10.3389/fendo.2023.1125822
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author Liu, Huazhen
Gao, Dan
Huang, Yongfa
Li, Ji
Zhao, Mengyun
Lu, Zhaohui
Hu, Ya
Wang, Tao
Zhang, Yingqiang
Wang, Wenze
Cao, Dongyan
author_facet Liu, Huazhen
Gao, Dan
Huang, Yongfa
Li, Ji
Zhao, Mengyun
Lu, Zhaohui
Hu, Ya
Wang, Tao
Zhang, Yingqiang
Wang, Wenze
Cao, Dongyan
author_sort Liu, Huazhen
collection PubMed
description Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevated level of PTH and calcium decreased immediately after cytoreductive surgery (CRS). The pathology confirmed mismatch repair (MMR)-deficient endometrial carcinoma with PTH expression. The patient received four-course chemotherapy and one-course immunotherapy after CRS. The disease progression led to multiple organ failure and death about five months after CRS. To our knowledge, this is the first case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secreting and the first report of malignancy associated hypercalcemia complicated with nodular goiter.
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spelling pubmed-99272092023-02-15 Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone Liu, Huazhen Gao, Dan Huang, Yongfa Li, Ji Zhao, Mengyun Lu, Zhaohui Hu, Ya Wang, Tao Zhang, Yingqiang Wang, Wenze Cao, Dongyan Front Endocrinol (Lausanne) Endocrinology Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevated level of PTH and calcium decreased immediately after cytoreductive surgery (CRS). The pathology confirmed mismatch repair (MMR)-deficient endometrial carcinoma with PTH expression. The patient received four-course chemotherapy and one-course immunotherapy after CRS. The disease progression led to multiple organ failure and death about five months after CRS. To our knowledge, this is the first case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secreting and the first report of malignancy associated hypercalcemia complicated with nodular goiter. Frontiers Media S.A. 2023-01-31 /pmc/articles/PMC9927209/ /pubmed/36798668 http://dx.doi.org/10.3389/fendo.2023.1125822 Text en Copyright © 2023 Liu, Gao, Huang, Li, Zhao, Lu, Hu, Wang, Zhang, Wang and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Huazhen
Gao, Dan
Huang, Yongfa
Li, Ji
Zhao, Mengyun
Lu, Zhaohui
Hu, Ya
Wang, Tao
Zhang, Yingqiang
Wang, Wenze
Cao, Dongyan
Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title_full Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title_fullStr Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title_full_unstemmed Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title_short Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
title_sort case report: life-threatening hypercalcemia associated with mmr-deficient endometrial carcinoma secreting parathyroid hormone
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927209/
https://www.ncbi.nlm.nih.gov/pubmed/36798668
http://dx.doi.org/10.3389/fendo.2023.1125822
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