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Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma

OBJECTIVE: To construct a nomogram based on preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma (PTC). METHODS: Preoperative clinical and ultrasound data from 709 patients diagnosed with solitary PTC between January 2017 and December 2020...

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Autores principales: Liu, Long, Jia, Chao, Li, Gang, Shi, Qiusheng, Du, Lianfang, Wu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927212/
https://www.ncbi.nlm.nih.gov/pubmed/36798828
http://dx.doi.org/10.3389/fonc.2023.1009958
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author Liu, Long
Jia, Chao
Li, Gang
Shi, Qiusheng
Du, Lianfang
Wu, Rong
author_facet Liu, Long
Jia, Chao
Li, Gang
Shi, Qiusheng
Du, Lianfang
Wu, Rong
author_sort Liu, Long
collection PubMed
description OBJECTIVE: To construct a nomogram based on preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma (PTC). METHODS: Preoperative clinical and ultrasound data from 709 patients diagnosed with solitary PTC between January 2017 and December 2020 were analyzed retrospectively. Univariate and multivariate logistic regression analyses were performed to identify the factors associated with PTC aggressiveness, and these factors were used to construct a predictive nomogram. The nomogram’s performance was evaluated in the primary and validation cohorts. RESULTS: The 709 patients were separated into a primary cohort (n = 424) and a validation cohort (n = 285). Univariate analysis in the primary cohort showed 13 variables to be associated with aggressive PTC. In multivariate logistic regression analysis, the independent predictors of aggressive behavior were age (OR, 2.08; 95% CI, 1.30-3.35), tumor size (OR, 4.0; 95% CI, 2.17-7.37), capsule abutment (OR, 2.53; 95% CI, 1.50-4.26), and suspected cervical lymph nodes metastasis (OR, 2.50; 95% CI, 1.20-5.21). The nomogram incorporating these four predictors showed good discrimination and calibration in both the primary cohort (area under the curve, 0.77; 95% CI, 0.72-0.81; Hosmer–Lemeshow test, P = 0.967 and the validation cohort (area under the curve, 0.72; 95% CI, 0.66-0.78; Hosmer–Lemeshow test, P = 0.251). CONCLUSION: The proposed nomogram shows good ability to predict PTC aggressiveness and could be useful during treatment decision making. ADVANCES IN KNOWLEDGE: Our nomogram—based on four indicators—provides comprehensive assessment of aggressive behavior of PTC and could be a useful tool in the clinic.
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spelling pubmed-99272122023-02-15 Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma Liu, Long Jia, Chao Li, Gang Shi, Qiusheng Du, Lianfang Wu, Rong Front Oncol Oncology OBJECTIVE: To construct a nomogram based on preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma (PTC). METHODS: Preoperative clinical and ultrasound data from 709 patients diagnosed with solitary PTC between January 2017 and December 2020 were analyzed retrospectively. Univariate and multivariate logistic regression analyses were performed to identify the factors associated with PTC aggressiveness, and these factors were used to construct a predictive nomogram. The nomogram’s performance was evaluated in the primary and validation cohorts. RESULTS: The 709 patients were separated into a primary cohort (n = 424) and a validation cohort (n = 285). Univariate analysis in the primary cohort showed 13 variables to be associated with aggressive PTC. In multivariate logistic regression analysis, the independent predictors of aggressive behavior were age (OR, 2.08; 95% CI, 1.30-3.35), tumor size (OR, 4.0; 95% CI, 2.17-7.37), capsule abutment (OR, 2.53; 95% CI, 1.50-4.26), and suspected cervical lymph nodes metastasis (OR, 2.50; 95% CI, 1.20-5.21). The nomogram incorporating these four predictors showed good discrimination and calibration in both the primary cohort (area under the curve, 0.77; 95% CI, 0.72-0.81; Hosmer–Lemeshow test, P = 0.967 and the validation cohort (area under the curve, 0.72; 95% CI, 0.66-0.78; Hosmer–Lemeshow test, P = 0.251). CONCLUSION: The proposed nomogram shows good ability to predict PTC aggressiveness and could be useful during treatment decision making. ADVANCES IN KNOWLEDGE: Our nomogram—based on four indicators—provides comprehensive assessment of aggressive behavior of PTC and could be a useful tool in the clinic. Frontiers Media S.A. 2023-01-31 /pmc/articles/PMC9927212/ /pubmed/36798828 http://dx.doi.org/10.3389/fonc.2023.1009958 Text en Copyright © 2023 Liu, Jia, Li, Shi, Du and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Long
Jia, Chao
Li, Gang
Shi, Qiusheng
Du, Lianfang
Wu, Rong
Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title_full Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title_fullStr Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title_full_unstemmed Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title_short Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
title_sort nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927212/
https://www.ncbi.nlm.nih.gov/pubmed/36798828
http://dx.doi.org/10.3389/fonc.2023.1009958
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