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Female reproductive tract-organ axes

The female reproductive tract (FRT) and remote/versatile organs in the body share bidirectional communication. In this review, we discuss the framework of the “FRT-organ axes.” Each axis, namely, the vagina-gut axis, uterus-gut axis, ovary-gut axis, vagina-bladder axis, vagina-oral axis, uterus-oral...

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Autores principales: Takada, Kazuhide, Melnikov, Vyacheslav G., Kobayashi, Ryoki, Komine-Aizawa, Shihoko, Tsuji, Noriko M., Hayakawa, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927230/
https://www.ncbi.nlm.nih.gov/pubmed/36798125
http://dx.doi.org/10.3389/fimmu.2023.1110001
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author Takada, Kazuhide
Melnikov, Vyacheslav G.
Kobayashi, Ryoki
Komine-Aizawa, Shihoko
Tsuji, Noriko M.
Hayakawa, Satoshi
author_facet Takada, Kazuhide
Melnikov, Vyacheslav G.
Kobayashi, Ryoki
Komine-Aizawa, Shihoko
Tsuji, Noriko M.
Hayakawa, Satoshi
author_sort Takada, Kazuhide
collection PubMed
description The female reproductive tract (FRT) and remote/versatile organs in the body share bidirectional communication. In this review, we discuss the framework of the “FRT-organ axes.” Each axis, namely, the vagina-gut axis, uterus-gut axis, ovary-gut axis, vagina-bladder axis, vagina-oral axis, uterus-oral axis, vagina-brain axis, uterus-brain axis, and vagina-joint axis, is comprehensively discussed separately. Each axis could be involved in the pathogenesis of not only gynecological diseases but also diseases occurring apart from the FRT. Although the microbiota is clearly a key player in the FRT-organ axes, more quantitative insight into the homeostasis of the microbiota could be provided by host function measurements rather than current microbe-centric approaches. Therefore, investigation of the FRT-organ axes would provide us with a multicentric approach, including immune, neural, endocrine, and metabolic aspects, for understanding the homeostatic mechanism of women’s bodies. The framework of the FRT-organ axes could also provide insights into finding new therapeutic approaches to maintain women’s health.
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spelling pubmed-99272302023-02-15 Female reproductive tract-organ axes Takada, Kazuhide Melnikov, Vyacheslav G. Kobayashi, Ryoki Komine-Aizawa, Shihoko Tsuji, Noriko M. Hayakawa, Satoshi Front Immunol Immunology The female reproductive tract (FRT) and remote/versatile organs in the body share bidirectional communication. In this review, we discuss the framework of the “FRT-organ axes.” Each axis, namely, the vagina-gut axis, uterus-gut axis, ovary-gut axis, vagina-bladder axis, vagina-oral axis, uterus-oral axis, vagina-brain axis, uterus-brain axis, and vagina-joint axis, is comprehensively discussed separately. Each axis could be involved in the pathogenesis of not only gynecological diseases but also diseases occurring apart from the FRT. Although the microbiota is clearly a key player in the FRT-organ axes, more quantitative insight into the homeostasis of the microbiota could be provided by host function measurements rather than current microbe-centric approaches. Therefore, investigation of the FRT-organ axes would provide us with a multicentric approach, including immune, neural, endocrine, and metabolic aspects, for understanding the homeostatic mechanism of women’s bodies. The framework of the FRT-organ axes could also provide insights into finding new therapeutic approaches to maintain women’s health. Frontiers Media S.A. 2023-01-31 /pmc/articles/PMC9927230/ /pubmed/36798125 http://dx.doi.org/10.3389/fimmu.2023.1110001 Text en Copyright © 2023 Takada, Melnikov, Kobayashi, Komine-Aizawa, Tsuji and Hayakawa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Takada, Kazuhide
Melnikov, Vyacheslav G.
Kobayashi, Ryoki
Komine-Aizawa, Shihoko
Tsuji, Noriko M.
Hayakawa, Satoshi
Female reproductive tract-organ axes
title Female reproductive tract-organ axes
title_full Female reproductive tract-organ axes
title_fullStr Female reproductive tract-organ axes
title_full_unstemmed Female reproductive tract-organ axes
title_short Female reproductive tract-organ axes
title_sort female reproductive tract-organ axes
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927230/
https://www.ncbi.nlm.nih.gov/pubmed/36798125
http://dx.doi.org/10.3389/fimmu.2023.1110001
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