A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer

The capsid protein (CA), an essential component of human immunodeficiency virus type 1 (HIV-1), represents an appealing target for antivirals. Small molecules targeting the CAI-binding cavity in the C-terminal domain of HIV-1 CA (CA CTD) confer potent antiviral activities. In this study, we report t...

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Detalles Bibliográficos
Autores principales: Zhang, Da-Wei, Xie, Liangxu, Xu, Xiao-Shuang, Li, Yimin, Xu, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927277/
https://www.ncbi.nlm.nih.gov/pubmed/36475726
http://dx.doi.org/10.1128/spectrum.02663-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927277/
https://www.ncbi.nlm.nih.gov/pubmed/36475726
http://dx.doi.org/10.1128/spectrum.02663-22

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