Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that potently reduced gene expression during HSV-1 lytic infection. HSV-1 is known to...

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Detalles Bibliográficos
Autores principales: Ly, Cindy Y., Pfannenstiel, Jessica, Pant, Anil, Yang, Zhilong, Fehr, Anthony R., Rodzkin, Maxim S., Davido, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927324/
https://www.ncbi.nlm.nih.gov/pubmed/36537798
http://dx.doi.org/10.1128/spectrum.01943-22

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