Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a combination of purchase and chemical synthesi...

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Detalles Bibliográficos
Autores principales: Bonnett, Shilah, Jee, Jo-Ann, Chettiar, Somsundaram, Ovechkina, Yulia, Korkegian, Aaron, Greve, Eric, Odingo, Joshua, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927457/
https://www.ncbi.nlm.nih.gov/pubmed/36688635
http://dx.doi.org/10.1128/spectrum.04974-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927457/
https://www.ncbi.nlm.nih.gov/pubmed/36688635
http://dx.doi.org/10.1128/spectrum.04974-22

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