Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization

Boosting protein production is invaluable in both industrial and academic applications. We discovered a novel expression-increasing 21-mer cis-regulatory motif (Exin21) that inserts between SARS-CoV-2 envelope (E) protein-encoding sequence and luciferase reporter gene. This unique Exin21 (CAACCGCGGT...

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Detalles Bibliográficos
Autores principales: Zhu, Yuanjun, Saribas, A. Sami, Liu, Jinbiao, Lin, Yuan, Bodnar, Brittany, Zhao, Ruotong, Guo, Qian, Ting, Julia, Wei, Zhengyu, Ellis, Aidan, Li, Fang, Wang, Xu, Yang, Xiaofeng, Wang, Hong, Ho, Wen-Zhe, Yang, Ling, Hu, Wenhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927791/
https://www.ncbi.nlm.nih.gov/pubmed/36793212
http://dx.doi.org/10.1016/j.ymthe.2023.02.012

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