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Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair
A triple‐layer matrix Collagen/Silk fibroin/Bioactive glass composited Nanofibrous was fabricated by linking electrospinning and freeze‐drying systems, this typical three layered composite with a nanofibrous fragment as the key (top) layer, middle portion as inferior, and a spongy porous fragment as...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927904/ https://www.ncbi.nlm.nih.gov/pubmed/36480641 http://dx.doi.org/10.1111/iwj.13910 |
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author | Yang, Minlie Yu, Shun Zhao, Peng Shi, Gaofeng Guo, Yun Xie, Longwei Lyu, Guozhong Yu, Junjie |
author_facet | Yang, Minlie Yu, Shun Zhao, Peng Shi, Gaofeng Guo, Yun Xie, Longwei Lyu, Guozhong Yu, Junjie |
author_sort | Yang, Minlie |
collection | PubMed |
description | A triple‐layer matrix Collagen/Silk fibroin/Bioactive glass composited Nanofibrous was fabricated by linking electrospinning and freeze‐drying systems, this typical three layered composite with a nanofibrous fragment as the key (top) layer, middle portion as inferior, and a spongy porous fragment as the third (bottom) deposit to develop the synergistic effect of composite materials resultant to physical and biological performances. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy were used to assess the final material's physicochemical properties (SEM). The triple‐layer matrix had a nanofibrous and porous structure, which has qualities including high porosity, swelling, and stability, which are important in soft‐tissue engineering. NIH 3 T3 fibroblast and humanoid keratinocyte (HaCaT) cell lines were also used to investigate the matrix's in vitro biological and fluorescent capabilities, which showed excellent cell adherence and proliferation across the composite layers. The synergistic arrangement of nanofibrous substantial deposition onto collagenous with silk fibroin candidates has therefore proven effective in the construction of a tri‐layer matrix for skin‐tissue‐engineering applications. |
format | Online Article Text |
id | pubmed-9927904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-99279042023-02-16 Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair Yang, Minlie Yu, Shun Zhao, Peng Shi, Gaofeng Guo, Yun Xie, Longwei Lyu, Guozhong Yu, Junjie Int Wound J Original Articles A triple‐layer matrix Collagen/Silk fibroin/Bioactive glass composited Nanofibrous was fabricated by linking electrospinning and freeze‐drying systems, this typical three layered composite with a nanofibrous fragment as the key (top) layer, middle portion as inferior, and a spongy porous fragment as the third (bottom) deposit to develop the synergistic effect of composite materials resultant to physical and biological performances. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy were used to assess the final material's physicochemical properties (SEM). The triple‐layer matrix had a nanofibrous and porous structure, which has qualities including high porosity, swelling, and stability, which are important in soft‐tissue engineering. NIH 3 T3 fibroblast and humanoid keratinocyte (HaCaT) cell lines were also used to investigate the matrix's in vitro biological and fluorescent capabilities, which showed excellent cell adherence and proliferation across the composite layers. The synergistic arrangement of nanofibrous substantial deposition onto collagenous with silk fibroin candidates has therefore proven effective in the construction of a tri‐layer matrix for skin‐tissue‐engineering applications. Blackwell Publishing Ltd 2022-12-08 /pmc/articles/PMC9927904/ /pubmed/36480641 http://dx.doi.org/10.1111/iwj.13910 Text en © 2022 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Yang, Minlie Yu, Shun Zhao, Peng Shi, Gaofeng Guo, Yun Xie, Longwei Lyu, Guozhong Yu, Junjie Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title | Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title_full | Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title_fullStr | Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title_full_unstemmed | Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title_short | Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
title_sort | fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927904/ https://www.ncbi.nlm.nih.gov/pubmed/36480641 http://dx.doi.org/10.1111/iwj.13910 |
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