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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling

Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here, we show that replacement of a single amino acid...

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Detalles Bibliográficos
Autores principales:	Nagao, Hirofumi, Cai, Weikang, Brandão, Bruna B., Wewer Albrechtsen, Nicolai J., Steger, Martin, Gattu, Arijeet K., Pan, Hui, Dreyfuss, Jonathan M., Wunderlich, F. Thomas, Mann, Matthias, Kahn, C. Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927934/ https://www.ncbi.nlm.nih.gov/pubmed/36548088 http://dx.doi.org/10.1172/JCI161472

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