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Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life

Pathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust genetic association between genes of innate immunity and AMD, genome-to-phenome relationships are low, suggesting a critical contribution of env...

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Detalles Bibliográficos
Autores principales:	Hata, Masayuki, Hata, Maki, Andriessen, Elisabeth M.M.A., Juneau, Rachel, Pilon, Frédérique, Crespo-Garcia, Sergio, Diaz-Marin, Roberto, Guber, Vera, Binet, Francois, Fournier, Frédérik, Buscarlet, Manuel, Grou, Caroline, Calderon, Virginie, Heckel, Emilie, Melichar, Heather J., Joyal, Jean-Sebastien, Wilson, Ariel M., Sapieha, Przemyslaw
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927938/ https://www.ncbi.nlm.nih.gov/pubmed/36787231 http://dx.doi.org/10.1172/JCI159757

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