SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis

SIPRα on macrophages binds with CD47 to resist proengulfment signals, but how the downstream signal of SIPRα controls tumor-infiltrating macrophages (TIMs) is still poorly clarified. Here, we report that the CD47/signal regulatory protein α (SIRPα) axis requires the deneddylation of tyrosine phospha...

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Detalles Bibliográficos
Autores principales: Li, Yiqing, Zhou, Hui, Liu, Pan, Lv, Dandan, Shi, Yichun, Tang, Bufu, Xu, Jiaqi, Zhong, Tingting, Xu, Wangting, Zhang, Jie, Zhou, Jianying, Ying, Kejing, Zhao, Yongchao, Sun, Yi, Jiang, Zhinong, Cheng, Hongqiang, Zhang, Xue, Ke, Yuehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927946/
https://www.ncbi.nlm.nih.gov/pubmed/36626230
http://dx.doi.org/10.1172/JCI162870

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