Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults

BACKGROUND: Mosaic and consensus HIV-1 immunogens provide two distinct approaches to elicit greater breadth of coverage against globally circulating HIV-1 and have shown improved immunologic breadth in nonhuman primate models. METHODS: This double-blind randomized trial enrolled 105 healthy HIV-unin...

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Detalles Bibliográficos
Autores principales: Cohen, Kristen W., Fiore-Gartland, Andrew, Walsh, Stephen R., Yusim, Karina, Frahm, Nicole, Elizaga, Marnie L., Maenza, Janine, Scott, Hyman, Mayer, Kenneth H., Goepfert, Paul A., Edupuganti, Srilatha, Pantaleo, Giuseppe, Hutter, Julia, Morris, Daryl E., De Rosa, Stephen C., Geraghty, Daniel E., Robb, Merlin L., Michael, Nelson L., Fischer, Will, Giorgi, Elena E., Malhi, Harmandeep, Pensiero, Michael N., Ferrari, Guido, Tomaras, Georgia D., Montefiori, David C., Gilbert, Peter B., McElrath, M. Juliana, Haynes, Barton F., Korber, Bette T., Baden, Lindsey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927951/
https://www.ncbi.nlm.nih.gov/pubmed/36787249
http://dx.doi.org/10.1172/JCI163338

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