A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4

Hereditary spastic paraplegia (HSP) is a group of degenerative neurological disorders. We identified a variant in human kinesin light chain KLC4 that is suspected to be associated with autosomal dominant HSP. How this and other variants relate to pathologies is unknown. We created a humanized C. ele...

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Detalles Bibliográficos
Autores principales: Gümüşderelioğlu, Selin, Resch, Lauren, Brock, Trisha, Luxton, G.W. Gant, Tan, Queenie K-G, Hopkins, Christopher, Starr, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928042/
https://www.ncbi.nlm.nih.gov/pubmed/36789438
http://dx.doi.org/10.1101/2023.01.07.523106

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