Cargando…

Pyruvate dehydrogenase complex integrates the metabolome and epigenome in memory T cell differentiation in vitro

BACKGROUND: Modulation of metabolic flux through pyruvate dehydrogenase complex (PDC) plays an important role in T cell activation and differentiation. PDC sits at the transition between glycolysis and the tricarboxylic acid cycle and is a major producer of acetyl-CoA, marking it as a potential meta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tarasenko, Tatiana N., Banerjee, Payal, Gomez-Rodriguez, Julio, Gildea, Derek, Zhang, Suiyuan, Wolfsberg, Tyra, Jenkins, Lisa M., McGuire, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928058/ https://www.ncbi.nlm.nih.gov/pubmed/36789409 http://dx.doi.org/10.21203/rs.3.rs-2464392/v1

Ejemplares similares

Pyruvate dehydrogenase complex integrates the metabolome and epigenome in CD8+ memory T cell differentiation in vitro
por: Tarasenko, Tatiana, et al.
Publicado: (2023)

Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire
por: Gordon-Lipkin, Eliza M., et al.
Publicado: (2023)

The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion
por: Varshney, Gaurav K., et al.
Publicado: (2013)

MLV integration site selection is driven by strong enhancers and active promoters
por: LaFave, Matthew C., et al.
Publicado: (2014)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Inhibition of pyruvate dehydrogenase kinase influence microbiota and metabolomic profile in pancreatic cancer xenograft mice
por: Adamberg, Kaarel, et al.
Publicado: (2020)

Effects of arsenic on pyruvate dehydrogenase activation.
por: Schiller, C M, et al.
Publicado: (1977)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

Classification and clustering analysis of pyruvate dehydrogenase enzyme based on their physicochemical properties
por: Banerjee, Amit Kumar, et al.
Publicado: (2010)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression
por: Meiser, Johannes, et al.
Publicado: (2016)

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
por: Ferriero, Rosa, et al.
Publicado: (2018)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
por: Yao, Yuan, et al.
Publicado: (2023)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury
por: Thibodeau, Alexa, et al.
Publicado: (2016)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Escherichia coli aceE variants coding pyruvate dehydrogenase improve the generation of pyruvate‐derived acetoin
por: Moxley, W. Chris, et al.
Publicado: (2023)

Oral Tolerance and Pyruvate Dehydrogenase in Patients with Primary Biliary Cirrhosis
por: Suzuki, Ayako, et al.
Publicado: (2002)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
por: Rajagopalan, Kartik N., et al.
Publicado: (2015)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy
por: Zeng, Zhenhua, et al.
Publicado: (2021)

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
por: Karissa, Patricia, et al.
Publicado: (2022)

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
por: Ogawa, Eri, et al.
Publicado: (2023)

The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation
por: Kolitsida, Panagiota, et al.
Publicado: (2023)

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
por: Bunik, Victoria I., et al.
Publicado: (2015)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

In vitro reconstitution and characterization of pyruvate dehydrogenase and 2‐oxoglutarate dehydrogenase hybrid complex from Corynebacterium glutamicum
por: Kinugawa, Hirokazu, et al.
Publicado: (2020)

Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress
por: Chalifoux, Olivia, et al.
Publicado: (2023)

Solution Structure and Characterisation of the Human Pyruvate Dehydrogenase Complex Core Assembly
por: Vijayakrishnan, S., et al.
Publicado: (2010)

Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex
por: Pei, Xue Yuan, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_cbjb50csftc81pcf56jrc37uuu