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Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial

INTRODUCTION: Autologous split thickness skin grafting is the standard-of-care for most deep dermal and full thickness skin defects. Historically, mesh grafting is used to expand skin grafts for smaller defects and other techniques such as Meek micrografting is used to enable expansion for larger sk...

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Autores principales: Rijpma, Danielle, Pijpe, Anouk, Claes, Karel, Hoeksema, Henk, de Decker, Ignace, Verbelen, Jozef, van Zuijlen, Paul, Monstrey, Stan, Meij-de Vries, Annebeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928116/
https://www.ncbi.nlm.nih.gov/pubmed/36787292
http://dx.doi.org/10.1371/journal.pone.0281347
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author Rijpma, Danielle
Pijpe, Anouk
Claes, Karel
Hoeksema, Henk
de Decker, Ignace
Verbelen, Jozef
van Zuijlen, Paul
Monstrey, Stan
Meij-de Vries, Annebeth
author_facet Rijpma, Danielle
Pijpe, Anouk
Claes, Karel
Hoeksema, Henk
de Decker, Ignace
Verbelen, Jozef
van Zuijlen, Paul
Monstrey, Stan
Meij-de Vries, Annebeth
author_sort Rijpma, Danielle
collection PubMed
description INTRODUCTION: Autologous split thickness skin grafting is the standard-of-care for most deep dermal and full thickness skin defects. Historically, mesh grafting is used to expand skin grafts for smaller defects and other techniques such as Meek micrografting is used to enable expansion for larger skin defects. Yet, Meek micrografting is increasingly used for smaller skin defects as well. Both techniques are frequently used, especially in burn centers, but evidence on which one is preferable for relative smaller skin defects is lacking. Therefore, an intra-patient randomized controlled trial was designed to adequately compare multiple outcomes of the Meek micrografting and mesh grafting techniques. MATERIALS AND METHODS: A multicenter intra-patient controlled randomized trial is being performed in two burn centers (the Netherlands and Belgium) to compare multiple outcomes of Meek micrografting and mesh grafting burns or skin defects. Study registration number (NL74274.029.20). Adult patients with a (burn) wound and an indication for surgical excision and skin grafting were screened for inclusion. In total 70 patients will be included and the primary outcome is scar quality twelve months post-surgery assessed by the Patient and Observer Scar Assessment Scale. Moreover, graft take, re-epithelialization, infection rate, donor site size and patients’ preference are also measured within hospital admission, on 3 months and 12 months post-surgery. DISCUSSION: This is the first randomized trial that is intra-patient controlled, which enables a proper comparison between both skin expansion techniques. The results of this study will contribute to the clarification of the indications of both techniques and ample attention is paid for the patients’ opinion on the surgical treatment options.
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spelling pubmed-99281162023-02-15 Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial Rijpma, Danielle Pijpe, Anouk Claes, Karel Hoeksema, Henk de Decker, Ignace Verbelen, Jozef van Zuijlen, Paul Monstrey, Stan Meij-de Vries, Annebeth PLoS One Study Protocol INTRODUCTION: Autologous split thickness skin grafting is the standard-of-care for most deep dermal and full thickness skin defects. Historically, mesh grafting is used to expand skin grafts for smaller defects and other techniques such as Meek micrografting is used to enable expansion for larger skin defects. Yet, Meek micrografting is increasingly used for smaller skin defects as well. Both techniques are frequently used, especially in burn centers, but evidence on which one is preferable for relative smaller skin defects is lacking. Therefore, an intra-patient randomized controlled trial was designed to adequately compare multiple outcomes of the Meek micrografting and mesh grafting techniques. MATERIALS AND METHODS: A multicenter intra-patient controlled randomized trial is being performed in two burn centers (the Netherlands and Belgium) to compare multiple outcomes of Meek micrografting and mesh grafting burns or skin defects. Study registration number (NL74274.029.20). Adult patients with a (burn) wound and an indication for surgical excision and skin grafting were screened for inclusion. In total 70 patients will be included and the primary outcome is scar quality twelve months post-surgery assessed by the Patient and Observer Scar Assessment Scale. Moreover, graft take, re-epithelialization, infection rate, donor site size and patients’ preference are also measured within hospital admission, on 3 months and 12 months post-surgery. DISCUSSION: This is the first randomized trial that is intra-patient controlled, which enables a proper comparison between both skin expansion techniques. The results of this study will contribute to the clarification of the indications of both techniques and ample attention is paid for the patients’ opinion on the surgical treatment options. Public Library of Science 2023-02-14 /pmc/articles/PMC9928116/ /pubmed/36787292 http://dx.doi.org/10.1371/journal.pone.0281347 Text en © 2023 Rijpma et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Rijpma, Danielle
Pijpe, Anouk
Claes, Karel
Hoeksema, Henk
de Decker, Ignace
Verbelen, Jozef
van Zuijlen, Paul
Monstrey, Stan
Meij-de Vries, Annebeth
Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title_full Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title_fullStr Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title_full_unstemmed Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title_short Outcomes of Meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: Study protocol for an intra-patient randomized controlled trial
title_sort outcomes of meek micrografting versus mesh grafting on deep dermal and full thickness (burn) wounds: study protocol for an intra-patient randomized controlled trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928116/
https://www.ncbi.nlm.nih.gov/pubmed/36787292
http://dx.doi.org/10.1371/journal.pone.0281347
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