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Representational integration and differentiation in the human hippocampus following goal-directed navigation

As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at...

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Autores principales: Fernandez, Corey, Jiang, Jiefeng, Wang, Shao-Fang, Choi, Hannah Lee, Wagner, Anthony D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928422/
https://www.ncbi.nlm.nih.gov/pubmed/36786678
http://dx.doi.org/10.7554/eLife.80281
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author Fernandez, Corey
Jiang, Jiefeng
Wang, Shao-Fang
Choi, Hannah Lee
Wagner, Anthony D
author_facet Fernandez, Corey
Jiang, Jiefeng
Wang, Shao-Fang
Choi, Hannah Lee
Wagner, Anthony D
author_sort Fernandez, Corey
collection PubMed
description As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at one level may seem to be at odds – both contribute to the emergence of structured knowledge. We tested this possibility using fMRI as human participants learned to navigate within local and global virtual environments over the course of 3 days. Pattern similarity analyses on entorhinal cortical and hippocampal patterns revealed evidence that differentiation and integration work concurrently to build local and global environmental representations, and that variability in integration relates to differences in navigation efficiency. These results offer new insights into the neural machinery and the underlying mechanisms that translate experiences into structured knowledge that allows us to navigate to achieve goals.
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spelling pubmed-99284222023-02-15 Representational integration and differentiation in the human hippocampus following goal-directed navigation Fernandez, Corey Jiang, Jiefeng Wang, Shao-Fang Choi, Hannah Lee Wagner, Anthony D eLife Neuroscience As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at one level may seem to be at odds – both contribute to the emergence of structured knowledge. We tested this possibility using fMRI as human participants learned to navigate within local and global virtual environments over the course of 3 days. Pattern similarity analyses on entorhinal cortical and hippocampal patterns revealed evidence that differentiation and integration work concurrently to build local and global environmental representations, and that variability in integration relates to differences in navigation efficiency. These results offer new insights into the neural machinery and the underlying mechanisms that translate experiences into structured knowledge that allows us to navigate to achieve goals. eLife Sciences Publications, Ltd 2023-02-14 /pmc/articles/PMC9928422/ /pubmed/36786678 http://dx.doi.org/10.7554/eLife.80281 Text en © 2023, Fernandez et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Fernandez, Corey
Jiang, Jiefeng
Wang, Shao-Fang
Choi, Hannah Lee
Wagner, Anthony D
Representational integration and differentiation in the human hippocampus following goal-directed navigation
title Representational integration and differentiation in the human hippocampus following goal-directed navigation
title_full Representational integration and differentiation in the human hippocampus following goal-directed navigation
title_fullStr Representational integration and differentiation in the human hippocampus following goal-directed navigation
title_full_unstemmed Representational integration and differentiation in the human hippocampus following goal-directed navigation
title_short Representational integration and differentiation in the human hippocampus following goal-directed navigation
title_sort representational integration and differentiation in the human hippocampus following goal-directed navigation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928422/
https://www.ncbi.nlm.nih.gov/pubmed/36786678
http://dx.doi.org/10.7554/eLife.80281
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