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Representational integration and differentiation in the human hippocampus following goal-directed navigation
As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928422/ https://www.ncbi.nlm.nih.gov/pubmed/36786678 http://dx.doi.org/10.7554/eLife.80281 |
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author | Fernandez, Corey Jiang, Jiefeng Wang, Shao-Fang Choi, Hannah Lee Wagner, Anthony D |
author_facet | Fernandez, Corey Jiang, Jiefeng Wang, Shao-Fang Choi, Hannah Lee Wagner, Anthony D |
author_sort | Fernandez, Corey |
collection | PubMed |
description | As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at one level may seem to be at odds – both contribute to the emergence of structured knowledge. We tested this possibility using fMRI as human participants learned to navigate within local and global virtual environments over the course of 3 days. Pattern similarity analyses on entorhinal cortical and hippocampal patterns revealed evidence that differentiation and integration work concurrently to build local and global environmental representations, and that variability in integration relates to differences in navigation efficiency. These results offer new insights into the neural machinery and the underlying mechanisms that translate experiences into structured knowledge that allows us to navigate to achieve goals. |
format | Online Article Text |
id | pubmed-9928422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-99284222023-02-15 Representational integration and differentiation in the human hippocampus following goal-directed navigation Fernandez, Corey Jiang, Jiefeng Wang, Shao-Fang Choi, Hannah Lee Wagner, Anthony D eLife Neuroscience As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration – which at one level may seem to be at odds – both contribute to the emergence of structured knowledge. We tested this possibility using fMRI as human participants learned to navigate within local and global virtual environments over the course of 3 days. Pattern similarity analyses on entorhinal cortical and hippocampal patterns revealed evidence that differentiation and integration work concurrently to build local and global environmental representations, and that variability in integration relates to differences in navigation efficiency. These results offer new insights into the neural machinery and the underlying mechanisms that translate experiences into structured knowledge that allows us to navigate to achieve goals. eLife Sciences Publications, Ltd 2023-02-14 /pmc/articles/PMC9928422/ /pubmed/36786678 http://dx.doi.org/10.7554/eLife.80281 Text en © 2023, Fernandez et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Fernandez, Corey Jiang, Jiefeng Wang, Shao-Fang Choi, Hannah Lee Wagner, Anthony D Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title | Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title_full | Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title_fullStr | Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title_full_unstemmed | Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title_short | Representational integration and differentiation in the human hippocampus following goal-directed navigation |
title_sort | representational integration and differentiation in the human hippocampus following goal-directed navigation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928422/ https://www.ncbi.nlm.nih.gov/pubmed/36786678 http://dx.doi.org/10.7554/eLife.80281 |
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