An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation (AF). We deleted the conserved mouse orthologues of t...

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Detalles Bibliográficos
Autores principales: Bosada, Fernanda M, van Duijvenboden, Karel, Giovou, Alexandra E, Rivaud, Mathilde R, Uhm, Jae-Sun, Verkerk, Arie O, Boukens, Bastiaan J, Christoffels, Vincent M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928424/
https://www.ncbi.nlm.nih.gov/pubmed/36715501
http://dx.doi.org/10.7554/eLife.80317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928424/
https://www.ncbi.nlm.nih.gov/pubmed/36715501
http://dx.doi.org/10.7554/eLife.80317

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