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Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)

The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML...

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Detalles Bibliográficos
Autores principales: Mizumaki, Hiroki, Ishiyama, Ken, Aoki, Jun, Mori, Jinichi, Mizuno, Shohei, Doki, Noriko, Fukuda, Takahiro, Uchida, Naoyuki, Onizuka, Masahito, Tanaka, Masatsugu, Katayama, Yuta, Ozawa, Yukiyasu, Ikegame, Kazuhiro, Takada, Satoru, Kawakita, Toshiro, Aotsuka, Nobuyuki, Atsuta, Yoshiko, Yanada, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928652/
https://www.ncbi.nlm.nih.gov/pubmed/36819182
http://dx.doi.org/10.1002/jha2.609
Descripción
Sumario:The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML patients with monosomy 7 or chromosome 7q deletion (‐7/del(7q)) using Japanese nationwide registry data. The der(1;7)(q10;p10) group showed significantly better transplant outcomes than the ‐7/del(7q) group. In the multivariate analysis of the der(1;7)(q10;p10) group, additional chromosomal abnormalities and a poor performance status significantly influenced the survival. In conclusion, allo‐SCT is a feasible treatment option for AML patients with der(1;7)(q10;p10).