Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)

The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML...

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Autores principales: Mizumaki, Hiroki, Ishiyama, Ken, Aoki, Jun, Mori, Jinichi, Mizuno, Shohei, Doki, Noriko, Fukuda, Takahiro, Uchida, Naoyuki, Onizuka, Masahito, Tanaka, Masatsugu, Katayama, Yuta, Ozawa, Yukiyasu, Ikegame, Kazuhiro, Takada, Satoru, Kawakita, Toshiro, Aotsuka, Nobuyuki, Atsuta, Yoshiko, Yanada, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928652/
https://www.ncbi.nlm.nih.gov/pubmed/36819182
http://dx.doi.org/10.1002/jha2.609
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author Mizumaki, Hiroki
Ishiyama, Ken
Aoki, Jun
Mori, Jinichi
Mizuno, Shohei
Doki, Noriko
Fukuda, Takahiro
Uchida, Naoyuki
Onizuka, Masahito
Tanaka, Masatsugu
Katayama, Yuta
Ozawa, Yukiyasu
Ikegame, Kazuhiro
Takada, Satoru
Kawakita, Toshiro
Aotsuka, Nobuyuki
Atsuta, Yoshiko
Yanada, Masamitsu
author_facet Mizumaki, Hiroki
Ishiyama, Ken
Aoki, Jun
Mori, Jinichi
Mizuno, Shohei
Doki, Noriko
Fukuda, Takahiro
Uchida, Naoyuki
Onizuka, Masahito
Tanaka, Masatsugu
Katayama, Yuta
Ozawa, Yukiyasu
Ikegame, Kazuhiro
Takada, Satoru
Kawakita, Toshiro
Aotsuka, Nobuyuki
Atsuta, Yoshiko
Yanada, Masamitsu
author_sort Mizumaki, Hiroki
collection PubMed
description The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML patients with monosomy 7 or chromosome 7q deletion (‐7/del(7q)) using Japanese nationwide registry data. The der(1;7)(q10;p10) group showed significantly better transplant outcomes than the ‐7/del(7q) group. In the multivariate analysis of the der(1;7)(q10;p10) group, additional chromosomal abnormalities and a poor performance status significantly influenced the survival. In conclusion, allo‐SCT is a feasible treatment option for AML patients with der(1;7)(q10;p10).
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spelling pubmed-99286522023-02-16 Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10) Mizumaki, Hiroki Ishiyama, Ken Aoki, Jun Mori, Jinichi Mizuno, Shohei Doki, Noriko Fukuda, Takahiro Uchida, Naoyuki Onizuka, Masahito Tanaka, Masatsugu Katayama, Yuta Ozawa, Yukiyasu Ikegame, Kazuhiro Takada, Satoru Kawakita, Toshiro Aotsuka, Nobuyuki Atsuta, Yoshiko Yanada, Masamitsu EJHaem Short Reports The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo‐SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML patients with monosomy 7 or chromosome 7q deletion (‐7/del(7q)) using Japanese nationwide registry data. The der(1;7)(q10;p10) group showed significantly better transplant outcomes than the ‐7/del(7q) group. In the multivariate analysis of the der(1;7)(q10;p10) group, additional chromosomal abnormalities and a poor performance status significantly influenced the survival. In conclusion, allo‐SCT is a feasible treatment option for AML patients with der(1;7)(q10;p10). John Wiley and Sons Inc. 2022-11-06 /pmc/articles/PMC9928652/ /pubmed/36819182 http://dx.doi.org/10.1002/jha2.609 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Mizumaki, Hiroki
Ishiyama, Ken
Aoki, Jun
Mori, Jinichi
Mizuno, Shohei
Doki, Noriko
Fukuda, Takahiro
Uchida, Naoyuki
Onizuka, Masahito
Tanaka, Masatsugu
Katayama, Yuta
Ozawa, Yukiyasu
Ikegame, Kazuhiro
Takada, Satoru
Kawakita, Toshiro
Aotsuka, Nobuyuki
Atsuta, Yoshiko
Yanada, Masamitsu
Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title_full Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title_fullStr Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title_full_unstemmed Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title_short Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
title_sort outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928652/
https://www.ncbi.nlm.nih.gov/pubmed/36819182
http://dx.doi.org/10.1002/jha2.609
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