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A Markovian model for the spread of the SARS-CoV-2 virus()

We propose a Markovian stochastic approach to model the spread of a SARS-CoV-2-like infection within a closed group of humans. The model takes the form of a Partially Observable Markov Decision Process (POMDP), whose states are given by the number of subjects in different health conditions. The mode...

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Autores principales: Palopoli, Luigi, Fontanelli, Daniele, Frego, Marco, Roveri, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928740/
https://www.ncbi.nlm.nih.gov/pubmed/36817632
http://dx.doi.org/10.1016/j.automatica.2023.110921
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author Palopoli, Luigi
Fontanelli, Daniele
Frego, Marco
Roveri, Marco
author_facet Palopoli, Luigi
Fontanelli, Daniele
Frego, Marco
Roveri, Marco
author_sort Palopoli, Luigi
collection PubMed
description We propose a Markovian stochastic approach to model the spread of a SARS-CoV-2-like infection within a closed group of humans. The model takes the form of a Partially Observable Markov Decision Process (POMDP), whose states are given by the number of subjects in different health conditions. The model also exposes the different parameters that have an impact on the spread of the disease and the various decision variables that can be used to control it (e.g, social distancing, number of tests administered to single out infected subjects). The model describes the stochastic phenomena that underlie the spread of the epidemic and captures, in the form of deterministic parameters, some fundamental limitations in the availability of resources (hospital beds and test swabs). The model lends itself to different uses. For a given control policy, it is possible to verify if it satisfies an analytical property on the stochastic evolution of the state (e.g., to compute probability that the hospital beds will reach a fill level, or that a specified percentage of the population will die). If the control policy is not given, it is possible to apply POMDP techniques to identify an optimal control policy that fulfils some specified probabilistic goals. Whilst the paper primarily aims at the model description, we show with numeric examples some of its potential applications.
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spelling pubmed-99287402023-02-15 A Markovian model for the spread of the SARS-CoV-2 virus() Palopoli, Luigi Fontanelli, Daniele Frego, Marco Roveri, Marco Automatica (Oxf) Article We propose a Markovian stochastic approach to model the spread of a SARS-CoV-2-like infection within a closed group of humans. The model takes the form of a Partially Observable Markov Decision Process (POMDP), whose states are given by the number of subjects in different health conditions. The model also exposes the different parameters that have an impact on the spread of the disease and the various decision variables that can be used to control it (e.g, social distancing, number of tests administered to single out infected subjects). The model describes the stochastic phenomena that underlie the spread of the epidemic and captures, in the form of deterministic parameters, some fundamental limitations in the availability of resources (hospital beds and test swabs). The model lends itself to different uses. For a given control policy, it is possible to verify if it satisfies an analytical property on the stochastic evolution of the state (e.g., to compute probability that the hospital beds will reach a fill level, or that a specified percentage of the population will die). If the control policy is not given, it is possible to apply POMDP techniques to identify an optimal control policy that fulfils some specified probabilistic goals. Whilst the paper primarily aims at the model description, we show with numeric examples some of its potential applications. Elsevier Ltd. 2023-05 2023-02-15 /pmc/articles/PMC9928740/ /pubmed/36817632 http://dx.doi.org/10.1016/j.automatica.2023.110921 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Palopoli, Luigi
Fontanelli, Daniele
Frego, Marco
Roveri, Marco
A Markovian model for the spread of the SARS-CoV-2 virus()
title A Markovian model for the spread of the SARS-CoV-2 virus()
title_full A Markovian model for the spread of the SARS-CoV-2 virus()
title_fullStr A Markovian model for the spread of the SARS-CoV-2 virus()
title_full_unstemmed A Markovian model for the spread of the SARS-CoV-2 virus()
title_short A Markovian model for the spread of the SARS-CoV-2 virus()
title_sort markovian model for the spread of the sars-cov-2 virus()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928740/
https://www.ncbi.nlm.nih.gov/pubmed/36817632
http://dx.doi.org/10.1016/j.automatica.2023.110921
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