Involvement of the GABAergic system in PTSD and its therapeutic significance

The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in th...

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Autores principales: Huang, Junhui, Xu, Fei, Yang, Liping, Tuolihong, Lina, Wang, Xiaoyu, Du, Zibo, Zhang, Yiqi, Yin, Xuanlin, Li, Yingjun, Lu, Kangrong, Wang, Wanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928765/
https://www.ncbi.nlm.nih.gov/pubmed/36818657
http://dx.doi.org/10.3389/fnmol.2023.1052288
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author Huang, Junhui
Xu, Fei
Yang, Liping
Tuolihong, Lina
Wang, Xiaoyu
Du, Zibo
Zhang, Yiqi
Yin, Xuanlin
Li, Yingjun
Lu, Kangrong
Wang, Wanshan
author_facet Huang, Junhui
Xu, Fei
Yang, Liping
Tuolihong, Lina
Wang, Xiaoyu
Du, Zibo
Zhang, Yiqi
Yin, Xuanlin
Li, Yingjun
Lu, Kangrong
Wang, Wanshan
author_sort Huang, Junhui
collection PubMed
description The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in the pathophysiological process of PTSD, with several studies demonstrating that the function of the GABAergic system decreases in PTSD patients. This paper reviews the preclinical and clinical studies, neuroimaging techniques, and pharmacological studies of the GABAergic system in PTSD and summarizes the role of the GABAergic system in PTSD. Understanding the role of the GABAergic system in PTSD and searching for new drug targets will be helpful in the treatment of PTSD.
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spelling pubmed-99287652023-02-16 Involvement of the GABAergic system in PTSD and its therapeutic significance Huang, Junhui Xu, Fei Yang, Liping Tuolihong, Lina Wang, Xiaoyu Du, Zibo Zhang, Yiqi Yin, Xuanlin Li, Yingjun Lu, Kangrong Wang, Wanshan Front Mol Neurosci Neuroscience The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in the pathophysiological process of PTSD, with several studies demonstrating that the function of the GABAergic system decreases in PTSD patients. This paper reviews the preclinical and clinical studies, neuroimaging techniques, and pharmacological studies of the GABAergic system in PTSD and summarizes the role of the GABAergic system in PTSD. Understanding the role of the GABAergic system in PTSD and searching for new drug targets will be helpful in the treatment of PTSD. Frontiers Media S.A. 2023-02-01 /pmc/articles/PMC9928765/ /pubmed/36818657 http://dx.doi.org/10.3389/fnmol.2023.1052288 Text en Copyright © 2023 Huang, Xu, Yang, Tuolihong, Wang, Du, Zhang, Yin, Li, Lu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Junhui
Xu, Fei
Yang, Liping
Tuolihong, Lina
Wang, Xiaoyu
Du, Zibo
Zhang, Yiqi
Yin, Xuanlin
Li, Yingjun
Lu, Kangrong
Wang, Wanshan
Involvement of the GABAergic system in PTSD and its therapeutic significance
title Involvement of the GABAergic system in PTSD and its therapeutic significance
title_full Involvement of the GABAergic system in PTSD and its therapeutic significance
title_fullStr Involvement of the GABAergic system in PTSD and its therapeutic significance
title_full_unstemmed Involvement of the GABAergic system in PTSD and its therapeutic significance
title_short Involvement of the GABAergic system in PTSD and its therapeutic significance
title_sort involvement of the gabaergic system in ptsd and its therapeutic significance
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928765/
https://www.ncbi.nlm.nih.gov/pubmed/36818657
http://dx.doi.org/10.3389/fnmol.2023.1052288
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