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Phase I study of novel SYK inhibitor TAK‐659 (mivavotinib) in combination with R‐CHOP for front‐line treatment of high‐risk diffuse large B‐cell lymphoma

Background: TAK‐659, a novel oral SYK inhibitor, has demonstrated efficacy in heavily pretreated diffuse large B‐cell lymphoma (DLBCL). We report results of a phase I single‐institution escalation study of front‐line treatment with R‐CHOP and TAK‐659 in treatment‐naïve high‐risk DLBCL. Methods: Pati...

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Detalles Bibliográficos
Autores principales:	Karmali, Reem, St‐Pierre, Frederique, Ma, Shuo, Foster, Kelly D., Kaplan, Jason, Mi, Xinlei, Pro, Barbara, Winter, Jane N., Gordon, Leo I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Haematologic Malignancy ‐ Lymphoid
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928783/ https://www.ncbi.nlm.nih.gov/pubmed/36819145 http://dx.doi.org/10.1002/jha2.625

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