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In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing

BACKGROUND: The core circadian gene Neuronal PAS domain 2 (NPAS2) is expressed in dermal fibroblasts and has been shown to play a critical role in regulating collagen synthesis during wound healing. We have performed high throughput drug screening to identify genes responsible for downregulation of...

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Detalles Bibliográficos
Autores principales: Clements, Adam, Shibuya, Yoichiro, Hokugo, Akishige, Brooks, Zachary, Roca, Yvonne, Kondo, Takeru, Nishimura, Ichiro, Jarrahy, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928850/
https://www.ncbi.nlm.nih.gov/pubmed/36816724
http://dx.doi.org/10.3389/fmed.2022.1014763